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FPGEE PDF DEMO:
QUESTION NO: 1
In an adequately powered, randomized controlled trial conducted over 3 years, a specific serious side
effect (i.e. reduction in leukocytes) with conventional therapy is seen in 0.5% of the study sample. In patients who receive a newly discovered drug, only 0.45% experience the same side effect. Based on these results, the minimum number of patients that would have to receive the new drug for 3 years to
statistically demonstrate the prevention of one episode of this side effect in at least one patient is:
A. 15.
B. 20.
C. 150.
D. 200.
E. 2000.
Answer: E
QUESTION NO: 2
Antimalarial drug used in the treatment of rheumatoid arthritis as DMRA-Disease-Modifying
Antirheumatic
Drug
A. Chloroquine
B. Quinine
C. Sulfasalazine
D. Hydroxycloroquine
E. Primaquine
Answer: D
QUESTION NO: 3
Which of the following are similarities between Cytochrome P450 and MAO?
A. Both add oxygen from O2 to substrates and also form water
B. Both carry out direct heteroatom oxidations
C. Both carry out oxidative deaminations
D. Both carry out N-dealkylations
E. All of the above
Answer: C
QUESTION NO: 4
Uricosuric agents are used in gout treatment by inhibiting the uric acid re-absorption in the proximal
tubules, the best example of a uricosuric agent is:
A. Allopurinol
B. sulphinpyrazone
C. Indomethacin
D. Penicillamine
E. Methotrexate
Answer: B
QUESTION NO: 5
Which of the following statements refers to foscavir?
A. Pyrophosphate analog
B. Metabolism in liver is by glucuronidization
C. Not shown to reduce sudden death or prolong survival.
D. Inhibition of DNA gyrase results in:
1 . Inhibition of bacterial replication 2. Inhibition of DNA repair 3. Inhibition of expression of certain operons
E. Non-nucleoside reverse transcriptase inhibitor
Answer: A
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Updated: May 26, 2022